Iranian Journal of Veterinary Surgery

Iranian Journal of Veterinary Surgery

Evaluation of Clinical Signs, Hematological and Biochemical Parameters after Blood Transfusion from Sheep to Goat

Document Type : Original Article

Authors
Omid Abdi 1
Vahid Najarnezhad 1
Vahid Mohammadi 2
1 Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
2 Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
10.30500/ivsa.2021.273976.1251
Abstract
Blood transfusion is needed for the treatment of severe anemia. The purpose of this study was to detect clinical reactions, hematological and biochemical alterations after a blood transfusion from sheep to goat. Four Iranian mixed breed male sheep and goats were used in this study. Fifteen milliliters per kilogram of whole blood was taken from the sheep. Blood transfusion to goats was performed after 24 hours. Blood samples were taken from goats at times 0 (10 min before transfusion), 10 min, 3, 6, 12, 24, 48, 72, 96, and 192 hours after blood transfusion. No reactions such as coughing, dyspnea, muscle tremors, salivation, tearing, fever, and ruminal bloating during and after blood transfusion were seen. The respiratory rate significantly increased, 3, 6, and 12 hours after blood transfusion (p ˂ 0.05). Hematocrit was significantly reduced 3 hours after blood transfusion (p ˂ 0.05). Serum creatinine levels were increased significantly 10 minutes and 3 hours after blood transfusion (p ˂ 0.05). Blood urea serum was significantly increased 6 and 12 hours after blood transfusion (p ˂ 0.05). Serum calcium levels were increased significantly 72 and 96 hours after blood transfusion (p ˂ 0.05). Serum magnesium levels were significantly increased 72 and 96 hours after blood transfusion (p ˂ 0.05). In conclusion, temporary and transient changes observed in this study were safe and were not life-threatening for the goats, and the sheep blood can be used in anemic goats for one time.
Keywords
Blood transfusion
Sheep
Goat
Subjects
  1. Bovens C, Gruffydd-Jones T. Xenotransfusion with canine blood in the feline species: review of the literature. Journal of Feline Medicine and Surgery, 2012; 15(2): 62-67.
  2. Chin-Yee I, Arya N, D’Almeida MS. The red cell storage lesion and its implication for transfusion. Transfusion and Apheresis Science, 1997; 18(3): 447-458.
  3. Sousa RS, Barrˆeto-J´unior RA, Sousa IKF. Evaluation of hematologic, Blood gas, and select biochemical variables in ovine whole blood stored in CPDA-1 bags. Veterinary Clinical Pathology, 2013; 42(1): 27-30.
  4. Zallen G, Offner PJ, Moore EE. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. The American Journal of Surgery, 1999; 178(6): 570-572.
  5. Leal-Noval SR, Jara-L´opez I, Garc´ıa-Garmendia JL. Influence of erythrocyte concentrate storage time on postsurgicalmorbidity in cardiac surgery patients. Anesthesiology, 2003; 98(4): 815-822.
  6. Hunt E, Wood B. Use of blood and blood products. Veterinary Clinics of North America: Food Animal Practice, 1999; 15(3): 641-662.
  7. Hunt E, Moore JS. Use of blood and blood products. Veterinary Clinics of North America: Food Animal Practice, 1990; 6(1): 133-147.
  8. Heddle NM. Pathophysiology of febrile nonhemolytic transfusion reactions. Current Opinion in Hematology, 1999; 6(6): 420-426.
  9. Najarnezhad V, Mohammadi V, Velayati M. Evaluation of clinical, hematological, and biochemical changes following autologous blood transfusion in goats. Comparative Clinical Pathology, 2016; 25: 429-435.
  10. Bonagura JD, Twedt DC. Kirk's Current Veterinary Therapy. Elsevier Health Sciences. Philadelphia, USA. 2013;
  11. Weiss DJ, Wardrop KJ. Schalms Veterinary hematology. 6th ed. Philadelphia: Wiley-Blackwell. 2010;
  12. Balcomb C, Foster D. Update on the Use of Blood and Blood Products in Ruminants. Veterinary Clinics Food Animal practice, 2014; 30: 455-474.
  13. Heinius G, Wladis A, Hahn RG, Kjellstro¨m BT. Induced Hypothermia and Rewarming after Hemorrhagic Shock. Journal of Surgical Research, 2002; 108: 7-13.
  14. Sousa RS, Chaves DF, Barrêto-Júnior RA, IFreitas Sousa IK, Soares HS, Barros IO. Clinical, haematological and biochemical responses of sheep undergoing autologous blood transfusion. BMC Veterinary Research, 2012; (61): 1-7.
  15. McPherson RA, Pincus MR. Henry's clinical diagnosis and management by laboratory methods. 22 ed. Philadelphia: Elsevier Health Sciences. 2011;
  16. Bracker K, Drellich S. Transfusion reactions. Compendium: Continuing Education for veterinarians, 2005; 22.
  17. Sarpataki O, Bedecean I, Codea R, Bel L, Catana R, Marcus I. Blood Transfusion with Canine Blood in Two Cats with Hypovolemic Anemia. Bulletin UASVM Veterinary Medicine, 2014; 71(2): 513-514.
  18. Nazifi S, Mashhadi Esmaeel MR. Clinical reactions and hematological and serum biochemical alterations in repeated blood transfusion from sheep to sheep. Scientific Research Iranian Veterinary Journal, 2005; 9&10: 5-13.
  19. Nielsen HJ, Reimert C, Pedersen AN, Dybkjoer E, Brünner N, Alsbjorn B. Leucocyte derived bioactive substances in fresh frozen plasma. British Journal of Anaesthesia, 1997; 78: 548–552.
  20. Kisielewicz C, Self I, Bell R. Assessment of Clinical and Laboratory Variables as a Guide to Packed Red Blood Cell Transfusion of Euvolemic Anemic Dogs. Journal of Veterinary Internal Medicine, 2014; 28: 576–582.
  21. Rozanski EA. Blood transfusion methods: time to reevaluate? Journal of Veterinary Emergency and Critical Care, 2011; 21(3): 184-185.
  22. McMichael MA, Smith SA, Galligan A, Swanson KS, Fan TM. Effect of Leukoreduction on Transfusion-Induced Inflammation in Dogs. Journal of Veterinary Internal Medicine, 2010; 24: 1131–1137.
  23. Fenwick JC, Cameron M, Ronco JJ, Wiggs BR, Tweeddale MG, Naiman SC. Blood transfusion as a cause of leucocytosis in critically ill patients. The Lancet, 1994; 334: 855–856.
  24. Duncan JR, Prasse KW, Mahaffey EA. Veterinary Laboratory Medicine: Clinical Pathology. Iowa State University Press. Amsterdam, Nederland, 1994;
  25. Thrall MA, Baker DC, Campbel TW, Denicola D, Fettman MJ, Lassen ED. Hematologia e bioquímica clínica veterinária. Rocca, São Paulo. 2006;
  26. Smith BP. Large animal internal medicine. 5 ed. United States, Elsevier Mosby. 2015;
  27. Meyer DJ, Harvey JW. Veterinary Laboratory Medicine: Interpretation & Diagnosis. W.B. Saunders. 1998.
Iranian Journal of Veterinary Surgery
Volume 16, Issue 2 - Serial Number 35
October 2021
Pages 128-134

  • Receive Date 20 February 2021
  • Revise Date 07 September 2021
  • Accept Date 02 October 2021
  • First Publish Date 02 October 2021